J Michael McIntosh Selected Research

Nicotinic Receptors (Nicotinic Acetylcholine Receptor)

11/2021	Computational and Functional Mapping of Human and Rat α6β4 Nicotinic Acetylcholine Receptors Reveals Species-Specific Ligand-Binding Motifs.
1/2021	Discovery of Methylene Thioacetal-Incorporated α-RgIA Analogues as Potent and Stable Antagonists of the Human α9α10 Nicotinic Acetylcholine Receptor for the Treatment of Neuropathic Pain.
1/2021	Selective Penicillamine Substitution Enables Development of a Potent Analgesic Peptide that Acts through a Non-Opioid-Based Mechanism.
1/2020	Behavioral and Molecular Basis of Cholinergic Modulation of Pain: Focus on Nicotinic Acetylcholine Receptors.
12/2019	RgIA4 Accelerates Recovery from Paclitaxel-Induced Neuropathic Pain in Rats.
10/2019	α-Conotoxin VnIB from Conus ventricosus is a potent and selective antagonist of α6β4* nicotinic acetylcholine receptors.
12/2018	Potent Antiglioblastoma Agents by Hybridizing the Onium-Alkyloxy-Stilbene Based Structures of an α7-nAChR, α9-nAChR Antagonist and of a Pro-Oxidant Mitocan.
11/2018	Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors.
1/2018	α9-containing nicotinic acetylcholine receptors and the modulation of pain.
1/2018	Nicotinic acetylcholine receptors in neuropathic and inflammatory pain.

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J Michael McIntosh Research Topics

Disease

28	Parkinson Disease (Parkinson's Disease) 12/2015 - 01/2002
18	Neuralgia (Stump Neuralgia) 11/2021 - 11/2006
18	Pain (Aches) 01/2021 - 11/2006
14	Tobacco Use Disorder (Nicotine Dependence) 01/2016 - 02/2006
8	Dyskinesias (Dyskinesia) 12/2015 - 06/2010
7	Inflammation (Inflammations) 01/2022 - 06/2007
6	Chronic Pain 01/2020 - 11/2011
6	Schizophrenia (Dementia Praecox) 12/2017 - 06/2007
5	Neoplasms (Cancer) 12/2018 - 01/2013
5	Parkinsonian Disorders (Parkinsonism) 12/2015 - 06/2010
4	Hyperalgesia 12/2019 - 11/2011
4	Acute Pain 01/2018 - 09/2012
3	Infections 01/2019 - 01/2013
3	Substance-Related Disorders (Drug Abuse) 11/2017 - 02/2012
3	Hypersensitivity (Allergy) 01/2016 - 09/2008
3	Nervous System Diseases (Neurological Disorders) 04/2009 - 02/2006
2	Ganglion Cysts (Ganglion) 01/2021 - 06/2005
2	Alzheimer Disease (Alzheimer's Disease) 09/2020 - 12/2015
2	Paralysis (Palsy) 01/2020 - 09/2002
2	Movement Disorders (Movement Disorder) 10/2019 - 08/2009
2	Wounds and Injuries (Trauma) 01/2018 - 01/2017
2	Substance Withdrawal Syndrome (Withdrawal Symptoms) 02/2015 - 08/2012
2	Autosomal Dominant Nocturnal Frontal Lobe Epilepsy 01/2013 - 09/2007
2	Mental Disorders (Mental Disorder) 11/2012 - 12/2007
2	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2006 - 12/2004
1	Tachycardia (Tachyarrhythmias) 01/2021
1	Heart Failure 01/2021
1	Intractable Pain 01/2021
1	Hypertension (High Blood Pressure) 01/2021
1	Anxiety Disorders (Anxiety Disorder) 01/2020
1	Adenocarcinoma 12/2018
1	Glioblastoma (Glioblastoma Multiforme) 12/2018
1	Carcinoma (Carcinomatosis) 08/2018
1	Diabetic Neuropathies (Diabetic Neuropathy) 01/2018
1	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 01/2018
1	Multiple Trauma (Multiple Injuries) 01/2018
1	Epilepsy (Aura) 12/2017
1	Tourette Syndrome (Tourette's Syndrome) 12/2017
1	Autistic Disorder (Autism) 12/2017
1	Confusion (Bewilderment) 01/2017
1	Cancer Pain 01/2017
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2016
1	Painful Neuropathy 01/2016

Drug/Important Bio-Agent (IBA)

48	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 11/2021 - 01/2002
31	Nicotine FDA Link 01/2016 - 08/2003
11	Analgesics (Analgesic Drugs)IBA 01/2018 - 11/2006
11	Dopamine (Intropin)FDA LinkGeneric 12/2013 - 09/2003
8	Peptides (Polypeptides)IBA 01/2021 - 08/2009
8	Levodopa (L Dopa)FDA LinkGeneric 12/2015 - 09/2003
7	Conotoxins (Conotoxin)IBA 01/2021 - 03/2008
6	LigandsIBA 11/2021 - 10/2002
5	Opioid Analgesics (Opioids)IBA 01/2021 - 01/2017
4	Nicotinic AgonistsIBA 01/2018 - 10/2006
4	Pharmaceutical PreparationsIBA 01/2016 - 03/2012
3	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2021 - 06/2005
3	Cholinergic Agents (Cholinergics)IBA 01/2021 - 09/2008
3	Neurotransmitter Agents (Neurotransmitter)IBA 01/2020 - 06/2007
3	CytokinesIBA 01/2019 - 01/2018
3	Adenosine Triphosphate (ATP)IBA 12/2018 - 01/2018
3	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2017 - 01/2016
2	Therapeutic UsesIBA 01/2021 - 01/2018
2	Proteins (Proteins, Gene)FDA Link 09/2020 - 01/2013
2	3- (5,6- dichloropyridin- 3- yl)- 3,6- diazabicyclo(3.2.0)heptaneIBA 12/2015 - 04/2014
2	VenomsIBA 10/2014 - 09/2002
2	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 02/2013 - 07/2007
2	Formaldehyde (Formol)FDA Link 09/2012 - 11/2011
2	Varenicline (Chantix)FDA Link 09/2012 - 08/2012
2	Antipsychotic Agents (Antipsychotics)IBA 03/2012 - 12/2007
2	MecamylamineIBA 06/2010 - 09/2007
2	alpha-conotoxin MIIIBA 06/2007 - 12/2004
1	Peptide Hydrolases (Proteases)FDA Link 01/2021
1	DisulfidesIBA 01/2021
1	Fentanyl (Sublimaze)FDA LinkGeneric 01/2021
1	Midazolam (Versed)FDA LinkGeneric 01/2021
1	Amyloid (Amyloid Fibrils)IBA 09/2020
1	Mollusk VenomsIBA 01/2020
1	Paclitaxel (Taxol)FDA LinkGeneric 12/2019
1	ethyleneIBA 12/2018
1	LipopolysaccharidesIBA 08/2018
1	Anti-Bacterial Agents (Antibiotics)IBA 08/2018
1	InterleukinsIBA 01/2018
1	Streptozocin (Streptozotocin)FDA Link 01/2018
1	C-Reactive ProteinIBA 01/2018
1	Acute-Phase Proteins (Acute-Phase Protein)IBA 01/2018
1	Biological ProductsIBA 01/2018
1	InflammasomesIBA 01/2018
1	Biomarkers (Surrogate Marker)IBA 01/2018
1	Interleukin-18 (Interleukin 18)IBA 01/2018
1	Interleukin-6 (Interleukin 6)IBA 01/2018
1	Leucovorin (Folinic Acid)FDA Link 01/2016
1	Fluorouracil (Carac)FDA LinkGeneric 01/2016
1	PlatinumIBA 01/2016
1	ABT-126IBA 12/2015

Therapy/Procedure

19	Therapeutics 01/2022 - 01/2002
6	Drug Therapy (Chemotherapy) 01/2021 - 09/2012
2	Ligation 01/2018 - 09/2008
2	Analgesia 01/2015 - 09/2012
1	Extracorporeal Membrane Oxygenation 01/2021
1	Injections 01/2020
1	Precision Medicine 11/2017